The playmaker was expected to be involved at the London Stadium today but has been left out – it is understood he did not even make the journey, casting more doubt over his Arsenal future.
And Gunners fans were shocked by the news that the £350,000-a-week star is not involved today.
He even took to Twitter yesterday to confirm he had completed a week of training, hinting he would return to the team today.
But that has proved not to be the case and Arsenal will have to make do without the World Cup winner once again – his last game for the club was on Boxing Day when he was dragged off at half-time against Brighton.
Plenty of people were unsurprisingly asking "Where is Ozil?" on Twitter and writing "No Ozil" after the shock omission.
One fan joked about Ozil's omission: "Negotiating a move to China hopefully."
Another said: "It seems like emery has an agenda against Ozil."
The club offered no immediate explanation for the German being left out.
There has been speculation Arsenal manager Unai Emery is not a fan of the playmaker, with him explaining earlier this season he left him out for "tactical reasons".
Laurent Koscielny is back in the Arsenal starting line-up while Hector Bellerin returns to make the bench.
The home side have a former Gunner of their own in for the derby.
Bellerin has not played since December 16 due to a calf strain but his return will certainly be well received by boss Unai Emery and Gunners fans.
Koscielny has been forced into a slightly quicker return from his Achilles injury over the last month.
The club captain missed the FA Cup win over Blackpool last week and Emery suggested he will need to manage Koscielny carefully throughout the remainder of the season.
But he captains the team today, with Arsenal lining up in a 3-4-3 formation.
Bernd Leno returns in goal with Koscielny, Shkodran Mustafi and Sokratis making up a back three.
Ainsley Maitland-Niles and Sead Kolasinac are at wing-back while Granit Xhaka and Matteo Guendouzi in midfield.
The front three for Arsenal is Pierre-Emerick Aubameyang, Alexandre Lacazette and Alex Iwobi.
For the Hammers, Samir Nasri makes his first Premier League start since a 4-2 defeat at Southampton for Manchester City in May 2016.
And Marko Arnautovic starts in attack despite being linked with a move to China this week.
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