Kim and Khloe Kardashian's fans react amid diet drug speculation

‘You look hungry’: Kim and Khloe Kardashian’s fans react after sisters pose together looking skinnier than ever amid yet more speculation that they’ve used Hollywood’s favorite new diet drug

Khloé Kardashian has previously tried to shut down speculation that she used the weight-loss drugs to help her slim down.

But she and her sister Kim Kardashian, 42, were beset by fan speculation that they had been using a popular anti-diabetes drug when they posted photos of their newly chiseled abs on Monday.

Several fans and critics called out the famous sisters for supposedly using weight-loss substances, despite their denials and a lack of concrete evidence that they had used Semaglutide, which is also known by the brand names Ozempic, Wegovy and Rybelsus.

Some fans even went as far as to accuse the reality stars of shooting an ad for Ozempic due to their significant weight loss.

‘An Ozempic ad is what I see here,’ wrote one accusatory account in the comments to their Instagram posts.

Picture perfect: Kim Kardashian, 42, and her sister Khloé, 38, were beset by comments speculating that they had used popular anti-diabetes drugs to lose weight after they showcased their rock-solid abs on Instagram on Monday

My how they’ve changed: The stars both proudly showcased their much trimmer bodies

Before: Kim, who calls herself a ‘shapeshifter’, is pictured here in a candid snap in 2017. Khloe is pictured right in 2018

Another person joked, ‘Save some insulin for the people who actually need it,’ though the drugs that many fans speculated that they had been using are distinct from the insulin that many diabetic people require.

Others complained more generally about the sisters’ weight loss, insisting that they were ‘too slim.’  

One particularly cruel comment appeared to be directed at Khloé: ‘Her hands look too thin eat something you look hungry.’

Another user joked that Khloé was ‘barely flexing,’ while Kim was ‘holding it in.’ 

Another user bemoaned the ‘money spent on those bodies.’ 

Other users complained more generally about Kim and Khloé’s recent weight loss, though Khloé’s physical transformation has been more gradual, and she has regularly highlighted her intense workouts for years.

‘What are yall trying to see who can show all their ribs the fastest???wtf,’ commented one person.

Others sounded nostalgic for the sisters’ curves of years past. 

Pointing fingers: Some fans even went as far as to accuse the reality stars of shooting an ad for Ozempic due to their significant weight loss. The drug is one brand name of Semaglutide, which suppresses appetite and is intended for people with type 2 diabetes

Ouch: One particularly cruel comment appeared to be directed at Khloé: ‘Her hands look too thin eat something you look hungry,’ while another person joked that Khloé was ‘barely flexing’ while Kim was ‘holding it in’

Wasteful: Another user bemoaned the ‘money spent on those bodies’

Lashing out: Other users complained more generally about Kim and Khloé’s recent weight loss, though Khloé’s physical transformation has been more gradual, and she has regularly highlighted her intense workouts for years

Having a laugh: Although Khloé described herself and Kim as Calabasas girls in her caption, one user suggested ‘Ozempic girls’ might be more accurate

Harming others: While wealthy customers have flocked to get Ozempic prescriptions to lose weight, its popularity has led to shortages for people who have type 2 diabetes and actually need it

‘When are you guys gonna bring curvy back….asking for a friend,’ read one critical comment.

Although Khloé described herself and Kim as Calabasas girls in her caption, one user suggested ‘Ozempic girls’ might be more accurate.

Another person simply wrote, ‘Somebody please feed them 😬.’ 

Ozempic is manufactured by Danish pharmaceutical giant Novo Nordisk and costs around $900 per dose.

The injectable version can be used on the stomach, thigh or arm, and it quickly works to suppress a person’s appetite, which can be useful in allowing them to shed weight.

It is currently only approved by the FDA as a type 2 diabetes treatment, but many medical providers have begun prescribing it off label as a weight-loss drug recently, and it has skyrocketed in popularity among wealthy customers looking to slim down.

However, the rush of rich people looking to buy the drug has created shortages that harm diabetic people who most need it for their health. 

Despite several of the negative comments, Kim and Khloé were still showered with plenty of praise for the stellar physiques. 

The duo — who each recently shared photos of their combined broods — matched each other in gray and black versions of the same outfit.

Both were tantalizing as they flashed their ample and perky cleavage in plunging bra tops.

Social media: Kim and Khloe put on a sizzling display in their photos shared to Instagram on Monday. They wore looks designed to showcased their new abs

Picture perfect: The 42-year-old mogul and her younger sibling, 38, looked like dolls as they bared their enviable abs

Smokin’ hot: Both were tantalizing as they flashed their ample and perky cleavage in plunging bra tops

Kim wrote in the caption of her post, ‘Kiki & Koko,’ and added an infinity emoji.

The family members zeroed in on their sex appeal as they showed off their vixen-like qualities. 

Kim’s low-slung skirt was set beautifully on her curvy hips, flattering her figure as it draped over her.

She played up the placement of the piece as she donned a glinting diamond chain around her belly.

Her maxi skirt featured a thigh-high slit that flashed her toned and tanned leg and showed off a sparkling anklet around her ankle.

Additionally, the billionaire businesswoman wore a diamond-encrusted ‘KIM’ nameplate necklace.

Transformation: Khloe proudly put her tiny waist on show in racy bikini snaps on Monday 

The former Mrs. West wore her lustrous dark locks in a center part as she let the butt-length tresses tumble down her back and over her shoulder. 

The superstar was typically gorgeous with her world-recognized visage made up to perfection.

She looked glowy with her eyebrows arched, eyes highlighted with fluffy lashes, and her cheeks blushed.

Meanwhile, Khloe contrasted her big sister as she went for a darker version of the ensemble. 

The mom-of-two, who shares daughter True and a baby son with ex Tristan Thompson, wowed as she put her individual touch on the look.

The Good American co-founder looked like a pinup doll as she modeled her onyx skirt, which had a slightly higher waistband than Kim’s.

She put her taut abdomen front and center as she struck several poses with the second-born Kardashian.

Khloe accented her presentation with a pop of a classic bright red color via a matching manicure and pedicure.

Known for their distinct tastes in nails — Khloe rocked a long and sharp style while Kim went with a short, nude option.

The blonde bombshell wore dainty necklaces and stacked bangles on one wrist.

Her honey-hued hair was arranged into an intentionally messy mop of curls set at the top of her head.

Flirty and long loose pieces were left out in front, providing a frame for the rest of the look.

Hair stylist Chris Appleton, who made an appearance in two of the carousel photos, commented: ‘That’s HOT.’

Fitness routine: Kim shared a POV snapshot from the gym and wrote ‘sister workouts are good for the soul’

And the ladies’ youngest sibling Kylie Jenner, 25, also passed through to leave a note that said, ‘cutest.’

In the series of images the media fixtures were in a neutral-toned space as they posed on a wide staircase.

Other shots showed Khloe standing against an oatmeal-colored wall as Chris stood near a professional studio light.

Kim crouched down on the floor in a pair of Yeezy slides as she held a digital camera in her hand to take snapshots of Khloe.

Fans have seen Kim and Khloe’s sisterly bond grow tremendously in recent years, and it was reported that the latter leaned on her older sibling through her tumultuous relationship with ex Tristan.

Speaking on the Not Skinny But Not Fat podcast earlier this year, their sister Kourtney Kardashian, 43, dished on the change in her and Khloe’s dynamic.

‘I think that when Khloe was pregnant with True and Kim had a surrogate at that time, I felt like they really bonded,’ the mom-of-three speculated.

‘They were going through the same things,’ she added.

At the time, Kourtney admitted to feeling ‘unhappy with the show’ because she felt her sisters were ‘ganging up’ on her.

In the past year Kim and Khloe have enjoyed the Met Gala together and a trip to Miami Art Basel months ago.

They’re often seen on social media together documenting their workouts or quality time with their kids, nieces and nephews.

The truth behind the TikTok diet drug craze – Hollywood is apparently hooked on it, and social media is fanning demand for the latest weight-loss ‘miracle’

Over the summer I was lucky enough to be invited to a 60th birthday at which the after-dinner entertainment was a private performance by one of the UK’s leading male pop stars. More eye-popping than the actual show, though, was how incredible said star looked. He was a mere shadow of his former self, prancing around the stage in a silver catsuit. His secret? Semaglutide, or Ozempic as it is branded, a new diet drug that everybody – but everybody, darling, including one of the world’s most famous supermodels – is apparently taking. 

Originally developed to treat type 2 diabetes, it is used off-label (for a purpose other than that for which it was licensed) in both the US and the UK to treat obesity. In research conducted by its billionaire manufacturer, the Danish-based pharmaceutical company Novo Nordisk, patients lost an average of 17 per cent of their overall body weight over 68 weeks. This compares with five to nine per cent for ‘oldschool’ anti-obesity drugs such as Metformin. 

Only available in the UK on the NHS if you have type 2 diabetes, Ozempic can be obtained through a private doctor, and if you are willing to take it without medical supervision – not recommended by doctors (see panel) – you can get it online through various weight-loss programmes. It is sometimes taken in tablet form but more commonly as an injection. 

Originally developed to treat type 2 diabetes, Semaglutide is used off-label. It has been branded as a new diet drug that everybody is apparently taking

Predictably, Hollywood has been aware of Ozempic for a lot longer than us – Variety magazine recently quipped that the drug deserved its own thank-you speech at the Emmys, as so many stars on the podium had obviously been taking it. Elon Musk raved about its more powerful sister drug, Wegovy, on Twitter; Kim Kardashian, it is hotly rumoured, used semaglutide to lose 16lb in order to fit into Marilyn Monroe’s dress for the Met Ball. On TikTok the hashtag #ozempic has had more than 285 million views. 

Thanks to the hype, there has been a surge in demand, causing shortages on both sides of the Atlantic, with a backlash against influencers and celebrities hogging supplies ahead of desperate diabetes sufferers. Predictably, Big Pharma has come up with an alternative – tirzepatide (brand name Mounjaro), manufactured by Eli Lilly – but it has yet to be approved by the US Food & Drug Administration for weight loss. 

Novo Nordisk has issued a statement to say its supplies will be replenished by the end of the year, but it hasn’t quelled anxiety. At least two middle-aged male friends of mine who started using it in September are getting themselves in a twist about being caught short before the holidays. As one private London GP remarked to me: ‘It’s like the H RT panic last spring.’ 

So what exactly is this drug? Semaglutide belongs to a class called GLP-1 agonists, which not only regulate blood sugar but, as was discovered about a decade ago, also mimic the gut hormones that regulate our appetites – the ones that tell the brain when we are hungry or full. There are, of course, side effects: acid reflux, nausea, exacerbation of IBS symptoms and fatigue (but much less so than in earlier GLP-1 agonists such as Saxenda), as well as pancreatitis, gallstones and, in very high doses, it has caused thyroid tumours in rats. Meanwhile, when you stop using it the effect wears off immediately and in some cases it won’t work at all. 

‘I would describe semaglutide as an example of very smart science,’ says leading consultant endocrinologist Dr Efthimia Karra from her private practice off London’s Harley Street. ‘But it is not a panacea for everyone. Around a fifth of users do not respond to it. This is because the human body favours weight gain, thus when you lose weight the body will do anything to revert to its highest BMI. The heavier you are the harder it is to lose weight. If a patient has made no progress in three months, I will take them off it.’ 

Banker’s wife Laura, a native New Yorker in her mid-50s who had hovered between decades, started using it in January. ‘The Paleo diet, 5:2, CBT, NLP, bootcamp, diet delivery services – I’ve tried them all,’ she says from the family home in Hampshire, ‘and I’ve always yo-yoed right back. After my last annual checkup I seriously contemplated giving up. Then my doctor suggested semaglutide.’ 

After only a month she noticed her clothes had become looser. From then on, the weight started dropping off. ‘The strange thing was, I wasn’t eating anything different. I just couldn’t physically have seconds any more, and the idea of pudding after a full meal had lost its allure.’ Three months on, she is two stone lighter ‒ though occasionally she suffers heartburn if she eats too late at night or drinks alcohol ‒ and when we spoke in autumn, she was looking forward to losing another stone by Christmas. 

‘There is a niggling voice that tells me it is both risky and lazy to take a drug to lose weight, and I worry that it will all pile on again if I stop taking it. But if it does, I will seriously consider taking it indefinitely.’ 

Private London GP Dr Martin Galy has been prescribing semaglutide for about a year to clients who cannot lose the weight they gained in menopause. He has seen it have a transformational effect, too, on much younger women who suffer polycystic ovary syndrome. ‘PCOS sufferers are difficult to treat, and you can imagine how body image plays a very important part when it comes to self-esteem.’ 

But according to Tom Sanders, professor of nutrition and dietetics at King’s College London, it is not a magic bullet. Commenting on a study on semaglutide published in The New England Journal of Medicine in 2021, he says, ‘The challenge post-weight loss is to prevent a regain in weight,’ he wrote. It may prove to be useful in the short term, but ‘public health measures that encourage behavioural changes such as regular physical activity and moderating dietary energy intake are still needed’. 

That said, given our rising national obesity statistics and the escalation in accompanying health issues such as heart failure, cancer and obstructive sleep apnoea clogging up hospital beds, we’re going to need something. Semaglutide may be the rich person’s drug today, but might it be approved for more widespread use? Only time will tell.

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